A mild and efficient H2O2 oxygenation of N-heteroaromatic compounds to the amine N-oxides and KI deoxygenation back to the tertiary amine with hexaphenyloxodiphosphonium triflate

Khodaei Mohammad Mehdi<sup>*</sup>; Alizadeh Abdolhamid; Hezarkhani Hadis Afshar

doi:10.1007/s13738-018-1381-4

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A mild and efficient H2O2 oxygenation of N-heteroaromatic compounds to the amine N-oxides and KI deoxygenation back to the tertiary amine with hexaphenyloxodiphosphonium triflate

作者：Khodaei Mohammad Mehdi^*; Alizadeh Abdolhamid; Hezarkhani Hadis Afshar

来源：Journal of the Iranian Chemical Society, 2018, 15(8): 1843-1849.

DOI：10.1007/s13738-018-1381-4

摘要

A mild and efficient method for the oxidation of N-heteroaromatic compounds to the corresponding N-oxides using H2O2 in the presence of hexaphenyloxodiphosphnium triflate (Hendrickson reagent) in EtOH at room temperature was reported. This methodology presented relatively fast and selective reactions to afford the N-oxides in good yields. The reverse reactions, deoxygenation reactions, were also carried out under the same reaction conditions by KI to produce the tertiary amines.