A novel fluorescent probe for Hg2+ detection in a wide pH range and its application in living cell imaging

作者：Xu, Jing; Li, Honglin; Chen, Yanchi; Yang, Bing; Jiao, Qingcai^*; Yang, Yushun^*; Zhu, Hai-Liang^*

来源：Analytical Methods, 2018, 10(46): 5554-5558.

DOI：10.1039/c8ay01887a

• INORGANIC MERCURY
• SELECTIVE DETECTION
• IONS
• CHEMOSENSOR
• HG(II)
• CHEMODOSIMETER
• METHYLMERCURY
• ENVIRONMENT
• ABSORPTION
• SPECIATION

A novel fluorescent probe (XL-1) exhibited over 50-fold enhanced fluorescence in the presence of Hg2+ and no interference could be produced by other metal ions, anions and amino acids. The recognition mechanism was confirmed by NMR and HRMS. The most attractive point was that XL-1 could maintain a stable detection performance for Hg2+ in a wide pH range from 3.0 to 11.0, indicating that it is an effective tool for Hg2+ detection in different acid-base environments. Furthermore, the confocal fluorescence images demonstrated that XL-1 could be used for monitoring Hg2+ in living cells.

• 单位
  医药生物技术国家重点实验室; 南京大学