科研之友
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摘要
Population pharmacokinetics (PPK), which is based on the principle of statistics, can be used to estimate various inter- and intra-individual factors which affect pharmacokinetics. By using Bayesian estimator, PPK can predict individual pharmacokinetic parameters accurately. PPK is widely used in the immunosuppressive therapy with cyclosporine, tacrolimus, mycophenolic acid and sirolimus.
