A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

作者:Li Shi Ying; Liu Li Han; Jia Hui Zhen; Qiu Wen Xiu; Rong Lei; Cheng Hong; Zhang Xian Zheng*
来源:Chemical Communications, 2014, 50(80): 11852-11855.
DOI:10.1039/c4cc05008h

摘要

A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative.