Direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine: highly enantio- and diastereoselective one-pot synthesis of bromohydrins

作者：Kano Taichi; Shirozu Fumitaka; Maruoka Keiji^*

来源：Chemical Communications, 2010, 46(40): 7590-7592.

DOI：10.1039/c0cc02739a

One-pot stereoselective synthesis of bromohydrins as a useful chiral building block was achieved by the reaction of Grignard reagents with optically active alpha-bromoaldehydes, which were in situ generated by direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine (S)-3.

• 出版日期2010