A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction

作者：Kuo Po Hung; Kuo Jui Chang; Hsueh Hsiao Ting; Hsieh Jian Yu; Huang Yi Chun; Wang Tao; Lin Yen Hung; Lin Chih Ting; Yang Yao Joe; Lu Shey Shi^*

来源：IEEE Transactions on Biomedical Circuits and Systems, 2015, 9(6): 790-800.

DOI：10.1109/TBCAS.2015.2507618

• Biosensor
• CMOS
• lab-on-a-chip
• magnetic bead
• rapid blood test

A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 mu m CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor-alpha (TNF-alpha) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm(2)-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.

• 出版日期2015-12
• 单位中国科学院电工研究所; 长春大学