A novel C-terminal kinesin subfamily may be involved in chromosomal movement in Caenorhabditis is elegans

作者：Ali MY; Siddiqui ZK; Malik AB; Siddiqui SS^*

来源：FEBS Letters, 2000, 470(1): 70-76.

DOI：10.1016/S0014-5793(00)01258-8

• kinesin-like protein
• embryonic development
• C-terminal motor
• cell division
• chromosomal movement
• Caenorhabditis elegans

C-terminal kinesin motor proteins, such as the Drosophila NCD and yeast KAR3, are involved in chromosomal segregation. Previously we have described two orthologs of NCD in Caenorhabditis elegans, KLP-3 and KLP-17, which also participate in chromosome movement. Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16, Interestingly KLP-15 and KLP-16 form a unique class of C-terminal kinesins, distinct from the previously known C-terminal motors in other organisms, Using in situ hybridization and RNA interference assay, we show that although all of these motors mediate chromosome s

• 出版日期2000-3-17