Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes

作者：Rizzo Stanislao^*; Genovesi Ebert Federica; Vento Andrea; Cresti Federica; Miniaci Sofia; Romagnoli Maria Chiara

来源：Graefes Archive for Clinical and Experimental Ophthalmology, 2009, 247(11): 1471-1476.

DOI：10.1007/s00417-009-1131-5

• Persistent macular hole
• Pars plana vitrectomy
• Heavy silicone oil
• Densiron-68

To evaluate the efficacy and safety of the use of Densiron-68 as intraocular endotamponade for the treatment of persisting macular holes (persistent MHs).
Retrospective interventional case study on 23 consecutive eyes showing persistent MHs after unsuccessful primary surgery that underwent retreatment with pars plana vitrectomy and Densiron-68 filling. The main outcome measures were: anatomic closure evaluated with optical coherence tomography (OCT), final best-corrected visual acuity (BCVA), and postoperative complications.
A total of 23 patients (52-88 years) were studied. Pre-operative OCT showed full-thickness MH (mean size 560 A mu m) in all patients. Densiron-68 was left in situ for 1.5-3 months. Final follow-up time was 12 months after the last surgery. Postoperative OCT showed the complete closure of the PMH in 20 of 23 eyes. Pre-operative BCVA ranged from 20/200 to 20/630 (1.50-1.00 logMAR, mean 1.14). Final postoperative BCVA ranged from 20/30 to 20/400 (0.18-1.30 logMAR, mean. 0.61). Nineteen eyes (82%) showed a significant increase in visual acuity by at least three lines: 11 (47%) patients gained at least four lines. Three eyes remained unchanged (13%). One case deteriorated by two lines (4%). No major complications were recorded.
Retreatment with Densiron-68 filling was safe and achieved encouraging anatomic and functional results.

• 出版日期2009-11