A pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment

作者：Moutschen P; Bourhaba M; Frippiat F; Giot J B; Meuris C; Leonard P; Moutschen M^*

来源：Journal of Clinical Virology, 2011, 50(3): 247-248.

DOI：10.1016/j.jcv.2010.11.016

• Hantavirus infection
• Anti-TNF therapy
• Immunosuppression

We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture.

• 出版日期2011-3