Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression

作者：Hirahashi Junichi^*; Hanafusa Norio; Wada Takehiko; Arita Makoto; Hishikawa Keiichi; Hayashi Matsuhiko; Nangaku Masaomi

来源：Internal Medicine, 2015, 54(18): 2377-2382.

DOI：10.2169/internalmedicine.54.4623

• IgA nephropathy
• aspirin
• eicosapentaenoic acid
• steroids

Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.

• 出版日期2015
• 单位RIKEN