An Efficient, Scalable Process for Benzphetamine Hydrochloride

作者：Pramanik Chinmoy^*; Bapat Kiran; Chaudhari Ashok; Kulkarni Mukund G; Kolla Rangarao; Sompalli Srinivasarao; Tripathy Narendra K; Gurjar Mukund K

来源：Organic Process Research & Development, 2014, 18(4): 495-500.

DOI：10.1021/op400313y

Commercial manufacturing of benzphetamine hydrochloride along with its impurity profiling is disclosed. Deoxygenation of pseudoephedrine is reported with similar to 100% retention by shielding the amine group as its tert-butyl carbamate, which is very straightforward to eliminate at the end. Four unknown process-related impurities are isolated from the samples of final API and characterized on the basis of their NMR and mass spectral analysis. Structures of the isolated impurities are confirmed by independent syntheses and coinjecting with the isolated one.

• 出版日期2014-4