Bone Material Quality in Transiliac Bone Biopsies of Postmenopausal Osteoporotic Women After 3 Years of Strontium Ranelate Treatment

作者：Roschger Paul^*; Manjubala Inderchand; Zoeger Norbert; Meirer Florian; Simon Rolf; Li Chenghao; Fratzl Zelman Nadia; Misof Barbara M; Paschalis Eleftherios P; Streli Christina; Fratzl Peter; Klaushofer Klaus

来源：Journal of Bone and Mineral Research, 2010, 25(4): 891-900.

DOI：10.1359/jbmr.091028

• STRONTIUM RANELATE
• OSTEOPOROSIS
• BONE MATERIAL QUALITY
• QBEI
• SR-mu XRF
• FTIRI
• NANOINDENTATION

Strontium ranelate (SrR) is a relatively new treatment for osteoporosis In this study we investigated its potential impact on human bone material quality in transiliac bone biopsies from postmenopausal osteoporotic women treated 3 years with calcium and vitamin D plus either 2 g SrR per day or placebo. Bone mineralization density distribution (BMDD), strontium (Sr) concentration, collagen cross-link ratio, and indentation modulus were analyzed by quantitative backscattered electron imaging, electron-induced X-ray fluorescence analysis, synchrotron radiation induced micro X-ray fluorescence elemental mapping, Fourier transform infrared imaging, and nanoindentation, respectively The BMDD of SrR-treated patients was shifted to higher atomic numbers (Z(mean) + 1 5%, p < 05 versus placebo) We observed Sr being preferentially incorporated in bone packets formed during SrR treatment up to 6% atom fraction [Sr/(Sr + Ca)] depending on the SrR serum levels of the individuals (correlation r = 084, p = 018) Collagen cross-link ratio was preserved in SR-treated bone The indentation modulus was significantly decreased in younger versus older bone packets for both placebo- (-20.5%, p < 0001) and SrR-treated individuals (-24 3%, p < .001), whereas no differences were found between the treatment groups In conclusion, our findings indicate that after SrR treatment, Sr is heterogeneously distributed in bone and preferentially present in bone packets formed during treatment The effect of SrR on BMDD seems to be due mainly to the uptake of Sr and not to changes in bone calcium content Taken together, these data provide evidence that the investigated bone quality determin

• 出版日期2010-4