Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

作者：Sung Hoon Ki; Doh Kyung Oh; Son Joe Eun; Park Jin Gyoon; Bae Yunui; Choi Soojeong; Nelson Seana Mary Lunney; Cowling Rebecca; Nagy Kristina; Michael Iacovos P; Koh Gou Young; Adamson S Lee; Pawson Tony; Nagy Andras^*

来源：Cell Metabolism, 2013, 17(1): 61-72.

DOI：10.1016/j.cmet.2012.12.010

Vascular endothelial growth factor A (VEGF) is highly expressed in adipose tissue. Its role, however, has not been fully elucidated. Here, we reveal the metabolic role of adipose-VEGF by studying mice with deletion (VEGF(Ad Delta)) or doxycycline-inducible overexpression of a VEGF transgene (VEGF(AdTg)) in the adipose tissue. VEGF(Ad Delta) mice have reduced adipose vascular density and show adipose hypoxia, apoptosis, inflammation, and metabolic defects on a high-fat diet. In contrast, induction of VEGF expression in VEGF(AdTg) mice leads to increased adipose vasculature and reduced hypoxia. The latter changes are sufficient to counteract an established compromising effect of high-fat diet on the metabolism, indicating that metabolic misbalance is reversible by adipose vessel density increase. Our data clearly show the essential role of VEGF signaling for adequate adipose function. Besides revealing insights into the molecular mechanisms of obesity-related metabolic diseases, this study points to the therapeutic potential of increased adipose angiogenesis.

• 出版日期2013-1-8
• 单位河北医科大学