A simple and convenient synthesis of 3-[5-(trifluoromethyl)-1,2,3-triazol-4-yl]cinnamic acids from 4-aryl-6-(trifluoromethyl)-2H-pyran-2-ones and sodium azide

作者：Usachev Boris I^*; Usachev Sergey A; Roeschenthaler Gerd Volker; Sosnovskikh Vyacheslav Ya

来源：Tetrahedron Letters, 2011, 52(50): 6723-6725.

DOI：10.1016/j.tetlet.2011.09.149

• Trifluoromethylated 2-pyrones
• Sodium azide
• Trifluoromethylated triazoles
• Cinnamic acid derivatives
• Malonic acid derivatives

4-Aryl-6-(trifluoromethyl)-2H-pyran-2-ones and ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3-carboxylates react with sodium azide to produce highly functionalized CF3-1,2,3-triazoles: 3-[5-(trifluoromethyl)-1,2,3-triazol-4-yl]cinnamic acids and monoethyl esters of [5-(trifluoromethyl)-1,2,3-triazol-4-yl]arylmethylidene malonic acids.

• 出版日期2011-12-14