Angiogenic potential of YKL-40 in the dynamics of tumor niche

作者：Pouyafar Ayda; Heydarabad Milad Zadi; Mahboob Solt****i; Mokhtarzadeh Ahad; Rahbarghazi Reza^*

来源：Biomedicine & Pharmacotherapy, 2018, 100: 478-485.

DOI：10.1016/j.biopha.2018.02.050

• Cancer biology
• Angiogenesis
• YKL-40 factor

A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels, making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy.

• 出版日期2018-4