Azobenzene-bridged bile acid dimers: an interesting class of conjugates with conformation-controlled bioactivity

作者:Li, Weina; Li, Yan; Yin, Xianpeng; Liang, Yun; Li, Jian; Wang, Chen; Lan, Yue; Wang, Hui; Ju, Yong*; Li, Guangtao*
来源:Tetrahedron Letters, 2016, 57(23): 2539-2543.
DOI:10.1016/j.tetlet.2016.04.107

摘要

The synergetic combination of the distinct properties of azobenzene and bile acid could afford stable tweezer-like conformation with tunable hydrophilic and hydrophobic channels, thus increasing their antimicrobial activity toward both Gram-positive and Gram-negative bacteria, which can be conveniently switched off when the conformation turn back to the extended state.