Postnatal corticosteroids and risk of retinopathy of prematurity

作者：Movsas Tammy Z^*; Spitzer Alan R; Gewolb Ira H

来源：Journal of AAPOS, 2016, 20(4): 348-352.

DOI：10.1016/j.jaapos.2016.05.008

PURPOSE To investigate the association between postnatal steroids and retinopathy of prematurity (ROP) in neonates born with birth weights at the limit of viability (<500 g).
METHODS Data from the Pediatrix BabySteps Clinical Warehouse were retrospectively reviewed. The study population consisted of 1,472 neonates with birth weights of <500 g who were discharged alive from 167 NICUs between 1996 and 2013. Statistical significance for unadjusted comparisons between groups was determined using the chi(2) or t test. Logistic regression was used to calculate odds of ROP.
RESULTS In multivariate analysis, the odds of any ROP for steroid treated infants was 1.6 (95% CI, 1.2-2.2) compared to nontreated infants; the odds of advanced ROP was 1.7 (95% CI, 1.3-2.3).
CONCLUSIONS In our large study cohort of critically low birth weight infants ROP was more common in neonates exposed to postnatal steroids.

• 出版日期2016-8