Duration of Action of Bupivacaine Hydrochloride Used for Palatal Sensory Nerve Block in Infant Pigs

作者：Holman Shaina Devi^*; Gierbolini Norat Estela M; Lukasik Stacey L; Campbell Malone Regina; Ding Peng; German Rebecca Z

来源：JOURNAL OF VETERINARY DENTISTRY, 2014, 31(2): 92-95.

DOI：10.1177/089875641403100205

Bupivacaine hydrochloride is frequently used in veterinary dental procedures to reduce the amount of general anesthesia needed and to reduce post-procedural pain. The aim of this study was to develop a novel method to test local anesthetic duration in mammals. Six infant pigs were placed under deep/surgical anesthesia with 3 % isoflurane and oxygen while 0.5 ml of 0.5 % bupivacaine hydrochloride was injected to block the two greater palatine and the nasopalatine nerves. They were then maintained under light anesthesia with 0.5-1.0 % isoflurane. Beginning 15-minutes after the injection, 7 sites in the oral cavity were stimulated using a pointed dental waxing instrument, including 3 sites on the hard palate. The response or lack of response, to the stimulus was recorded on video and in written record. The bupivacaine hydrochloride injections lasted I to 3-hours before the animals responded to the sensory stimulation with a reflexive movement. This study provides evidence that bupivacaine used to anesthetize the hard palate has a relatively short and variable duration of action far below what is expected based on its pharmacokinetic properties.

• 出版日期2014