Anemia of Inflammation

作者：Nemeth, Elizabeta; Ganz, Tomas^*

来源：Hematology-Oncology Clinics of North America, 2014, 28(4): 671-+.

DOI：10.1016/j.hoc.2014.04.005

• Anemia of chronic disease
• Hepcidin
• Ferroportin
• Cytokines
• Erythropoiesis-stimulating agents

Anemia of inflammation (Al, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. It is diagnosed when serum iron concentrations are low despite adequate iron stores, as evidenced by serum ferritin that is not low. In the setting of inflammation, it may be difficult to differentiate Al from iron deficiency anemia, and the 2 conditions may coexist. Treatment should focus on the underlying disease. Recent advances in molecular understanding of Al are stimulating the development of new pathophysiologically targeted experimental therapies.

• 出版日期2014-8