A fiber optic probe design to measure depth-limited optical properties in-vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy

作者：Mutyal Nikhil N^*; Radosevich Andrew; Gould Bradley; Rogers Jeremy D; Gomes Andrew; Turzhitsky Vladimir; Backman Vadim

来源：Optics Express, 2012, 20(18): 19643-19657.

Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.

• 出版日期2012-8-27
• 单位西北大学