A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides

作者：Zhang Jian; Yin Zhi-Qi; Liang Jing-Yu^*

来源：Chinese Journal of Natural Medicines, 2013, 11(3): 274-276.

DOI：10.3724/SP.J.1009.2013.00274

• Trachelospermum jasminoides
• Isoflavonoid diglycoside
• Lignoid glycoside
• Cytotoxicity evaluation

AIM: To study the chemical constituents from the aerial parts of Trachelospermum jasminoides. METHODS: Compounds were isolated by various chromatographic methods and their structures were elucidated on the basis of spectral techniques. In addition, the inhibitory activity against HepG2 and HL-60 of compound 1 was evaluated. RESULTS: Five compounds were isolated and identified as 3', 7-dimethoxyisoflavanone-4', 5-di-O-beta-D-glucopyranoside (1), tracheloside (2), nortrachelogenin 5'-C-beta-glucopyranoside (3), luteolin-4'-O-beta-D-rutinoside (4), and luteolin-7-O-beta-D-glucopyranoside (5). CONCLUSION: Compound 1 is a new isoflavonoid glycoside. It showed weak inhibitory activity against HepG2 and HL-60 cancer cells with IC50 values of 131.5 and 58.2 mu mol.L-1, respectively.

• 出版日期2013-5
• 单位江苏省中医药研究院; 中国药科大学