Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older Women

作者：Slinin Yelena^*; Paudel Misti; Taylor Brent C; Ishani Areef; Rossom Rebecca; Yaffe Kristine; Blackwell Terri; Lui Li Yung; Hochberg Marc; Ensrud Kristine E

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2012, 67(10): 1092-1098.

DOI：10.1093/gerona/gls075

• Vitamin D
• Cognitive decline
• Executive function
• Cohort studies
• Risk factors in epidemiology

Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.
The study is a cross-sectional and longitudinal analysis of a prospective cohort of 6,257 community-dwelling elderly women followed for 4 years. Global cognitive function was measured by the Modified Mini-Mental State Examination and executive function was measured by Trail Making Test Part B (Trails B). Cognitive impairment at baseline was defined as a score > 1.5 SD below the sample mean; cognitive decline was defined as decline from baseline to follow-up > 1 SD from mean change in score.
Women with very low vitamin D levels had an increased odds of global cognitive impairment at baseline: odds ratio (95% confidence interval), 1.60 (1.05-2.42) for women with 25(OH)D < 10 ng/mL (25 nmol/L) compared with those with 25(OH)D levels >= 30 ng/mL (75 nmol/L). Compared with women with baseline 25(OH)D level >= 30 ng/mL (75 nmol/L), women with lower levels had an increased risk of global cognitive decline: odds ratio (95% confidence interval), 1.58(1.12-2.22) for women with levels < 10 ng/mL (25 nmol/L), and 1.31 (1.04-1.64) for those with levels 10-19.9 ng/mL (25-49 nmol/L). Levels of 25(OH)D were not associated with executive cognitive function.
Low 25(OH)D levels among older women were associated with a higher odds of global cognitive impairment and a higher risk of global cognitive decline.

• 出版日期2012-10