摘要
A new bergenin derivative, bergenin-11-O-alpha-D-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1-8) in LPS-stimulated murine macrophage RAW 264.7 cells were also investigated. Our results revealed that compound 1 inhibited the production of pro-inflammatory mediators NO and PGE(2) and the expression of NF-kappa B, TNF-alpha, IL-1 beta, iNOS and COX-2.
- 出版日期2016-8-1
- 单位广西师范大学