科研之友
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摘要
Enantioselective addition of styrenes to cyclic N-sulfonyl alpha-ketiminoesters was developed using the complex of Ni(ClO4)(2) with chiral phosphine complex as a catalyst. A range of chiral benzofused 5-membered sultams bearing alkenylated or allylated alpha-tetrasubstituted amino ester framework were afforded in excellent enantioselectivities (up to 99% ee) as potential biologically active compounds for drug research.
- 出版日期2015-11
- 单位浙江工业大学
