Aspirin 300 mg/day is effective for treating aspirin-exacerbated respiratory disease

作者：Comert S^*; Celebioglu E; Yucel T; Erdogan T; Karakaya G; Onerci M; Kalyoncu A F

来源：Allergy, 2013, 68(11): 1443-1451.

DOI：10.1111/all.12269

• aspirin desensitization treatment
• asthma
• desensitization
• rhinitis

BackgroundAspirin desensitization (AD) treatment at doses of up to 1300mg/day improves outcomes in aspirin-exacerbated respiratory disease (AERD). The aim of this study was to investigate the efficacy of aspirin 300mg/day in the treatment of patients with AERD. %26lt;br%26gt;MethodsThe study included 40 patients diagnosed in our clinic as AERD that were desensitized and treated with aspirin 300mg/day between December 2005 and December 2012. Changes from the baseline status were analyzed at 1year and at 3years of follow-up. %26lt;br%26gt;ResultsOf the 40 patients included, 24 (60%) were female and median (interquartile range [IQR]) age was 45 (40-51) years. Median (IQR) duration of AD was 31.5 (10.5-48.5) months. In total, 29 patients continued treatment for at least 1year and 18 patients for at least 3years. The annual rate of use of systemic corticosteroid regimens, episodes of sinusitis, and surgery was significantly lower both at 1year (P=0.002, P=0.01, and P%26lt;0.001, respectively) and at 3years (P=0.001, P=0.03, and P=0.002, respectively). Significant improvement was observed in the nasal congestion score (P=0.01) and sense of smell score (P=0.05) at 1year and in the postnasal drainage score (P=0.01) at 3years. %26lt;br%26gt;ConclusionDaily treatment with aspirin 300mg had beneficial effects in patients with AERD, especially for the control of upper airway disease.

• 出版日期2013-11