Association of CYP19 Gene Polymorphism with Vertebral Fractures in Japanese Postmenopausal Women

作者：Koudu Yasuko; Onouchi Tsuneko; Hosoi Takayuki; Horiuchi Toshiyuki^*

来源：Biochemical Genetics, 2012, 50(5-6): 389-396.

DOI：10.1007/s10528-011-9483-z

• Aromatase gene polymorphisms
• Vertebral fractures
• Postmenopausal women

This study investigates aromatase gene polymorphism, which might influence bone strength in terms of mineral density and quality. We explored the relationship between polymorphisms and vertebral fractures in postmenopausal Japanese women. In addition, we compared estrogen and testosterone levels in Japanese postmenopausal women with and without fractures. Osteoporotic postmenopausal women showed higher incidences of vertebral fractures than osteopenic women or women with normal lumbar bone mineral density (L2-4 BMD). Estrogen concentrations in postmenopausal women were associated with BMD; however, no association was found between sex hormone levels and the presence of fractures. The C allele rs2470152 was significantly associated with increased risk of vertebral fractures ( = 0.04), whereas none of the polymorphisms showed differences in sex steroid levels between subjects with and without fractures. Allelic variants of aromatase genes appear to interact to influence the risk of vertebral fractures in postmenopausal Japanese women.

• 出版日期2012-6