Analytical methods used in autism spectrum disorders

作者：Kaluzna Czaplinska Joanna^*; Jozwik Jagoda; Zurawicz Ewa

来源：TrAC-Trends in Analytical Chemistry, 2014, 62: 20-27.

DOI：10.1016/j.trac.2014.06.014

• Analytical method
• Autism
• Autism spectrum disorder
• Autistic child
• Biomarker
• Chromatography
• Etiology
• Mass spectrometry
• Metabolic profile
• Trace element

Autism is a neurodevelopmental brain disorder characterized by deficiencies of language and social interaction skills, and repetitive behaviors, and is often accompanied by hyperactivity and limited attention. There are numerous theories about the specific causes of autism but they have not yet been proved. Many studies have indicated that autism has a broad multifactorial etiology, with predisposing factors including exposure to toxic chemicals, nutrient deficiencies, and genetic susceptibility. Analytical methods are important in the determination of metabolites in biological samples from autistic children for potential use as biomarkers of the disorder. Metabolic profiling helps to understand the etiology of autism and aids in the development of new treatments.

• 出版日期2014-11