A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

作者：Montagut Gemma; Baiges Isabel; Valls Josep; Terra Ximena; del Bas Josep M; Vitrac Xavier; Richard Tristan; Merillon Jean Michel; Arola Lluis; Blay Mayte; Blade Cinta; Fernandez Larrea Juan; Pujadas Gerard; Salvado Josepa; Ardevol Anna^*

来源：Food Chemistry, 2009, 116(1): 265-270.

DOI：10.1016/j.foodchem.2009.02.044

• Dimer-gallate
• Procyanidin
• Trimer
• Glucose uptake
• Triacylglycerol secretion
• Cholesterol secretion
• Anti-inflammatory effect

The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6).

• 出版日期2009-9-1