A novel use of hill function and utility of Tc-99m-MIBI scintigraphy to detect earlier lower extremity microvascular perfusion in patients with type 2 diabetes

作者：Li, Yingsha; Li, Qiang; Liang, Shenju; Liang, Xia; Zhou, Wen; He, Hongbo; Jin, Rongbing; Wang, Kaifa; Zhu, Zhiming; Yan, Zhencheng^*

来源：Medicine, 2017, 96(38): e8038.

DOI：10.1097/MD.0000000000008038

• Tc-99m-MIBI scintigraphy
• lower extremity microvascular perfusion
• type 2 diabetes

We use the Hill function to analyze the dynamics of Tc-99m 2 methoxy-isobutyl-isonitrile (Tc-99m-MIBI) scintigraphy data and to examine the earlier lower extremity microvascular perfusion of diabetic patients without typical clinical symptoms and with the preserved normal ankle-brachial index (ABI).
Eighty-eight participants (30 healthy control, 34 diabetic patients, and 24 diabetic patients with peripheral arterial disease [PAD]) were recruited and applied 99mTc-MIBI scintigraphy. Fourteen diabetic patients with PAD also underwent computed tomography angiography (CTA) examination and were performed endovascular interventions.
Diabetic patients with normal ABI already have significantly impaired maximum 99mTc-MIBI muscle perfusion counts (P<.001) and the peak times of the lower extremity muscle perfusion (P<. 05). 99mTc-MIBI scintigraphy showed great consistent with ABI and CTA in detecting PAD. 99mTc-MIBI scintigraphy was also found to be effective in evaluating lower extremity circulation after endovascular interventions (P<. 05).
Hill function-based analysis of 99mTc-MIBI scintigraphy might be effective method to evaluate earlier lower extremity perfusion changes in diabetic patients.

• 出版日期2017-9
• 单位中国人民解放军陆军军医大学