Using non-enzymatic chemistry to influence microbial metabolism

作者：Wallace Stephen; Schultz Erica E; Balskus Emily P^*

来源：Current Opinion in Chemical Biology, 2015, 25: 71-79.

DOI：10.1016/j.cbpa.2014.12.024

The structural manipulation of small molecule metabolites occurs in all organisms and plays a fundamental role in essentially all biological processes. Despite an increasing interest in developing new, non-enzymatic chemical reactions capable of functioning in the presence of living organisms, the ability of such transformations to interface with cellular metabolism and influence biological function is a comparatively underexplored area of research. This review will discuss efforts to combine non-enzymatic chemistry with microbial metabolism. We will highlight recent and historical uses of non-biological reactions to study microbial growth and function, the use of non-enzymatic transformations to rescue auxotrophic microorganisms, and the combination of engineered microbial metabolism and biocompatible chemical reactions for organic synthesis.

• 出版日期2015-4