An alternative synthesis and X-ray crystallographic confirmation of (-)-stepholidine

作者：Gadhiya Satishkumar V; Hu Chunhua; Harding Wayne W^*

来源：Tetrahedron Letters, 2016, 57(19): 2090-2092.

DOI：10.1016/j.tetlet.2016.03.108

• Stepholidine
• THPB
• Tetrahydroprotoberberine
• Dopamine
• X-ray crystallography

A formal enantioselective synthesis of (-)-stepholidine that provides an alternative preparation of key lactone intermediate 2 is described. The stereostructure of (-)-stepholidine prepared via this method was confirmed by X-ray diffraction.

• 出版日期2016-5-11