Auto-oxidation promoted sp(3) C-H arylation of glycine derivatives

作者：Wei, Yuanyuan; Wang, Jie; Wang, Yajun; Yao, Xiaoqiang; Yang, Caixia; Huo, Congde^*

来源：Organic and Biomolecular Chemistry, 2018, 16(27): 4985-4989.

DOI：10.1039/c8ob01068d

• METABOTROPIC GLUTAMATE RECEPTORS
• CARBON-HYDROGEN BONDS
• COUPLING REACTION
• MOLECULAR-OXYGEN
• AMINO-ACIDS
• PHENYLGLYCINE DERIVATIVES
• BETA-HYDROXYSULFONES
• TERMINAL ALKYNES
• ESTERS
• FUNCTIONALIZATION

An auto-oxidation promoted sp(3) C-H arylation reaction between N-aryl glycine derivatives and electron-rich arenes, leading to the formation of N-aryl alpha-aryl alpha-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Bronsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.

• 出版日期2018-7-21
• 单位西北师范大学