A new synthesis of indoles via intramolecular cyclization of o-alkynyl N,N-dialkylanilines promoted by KOt-Su/DMSO

作者：Chen, Yan-yan; Chen, Jia-hua; Zhang, Niu-niu; Ye, Lin-miao; Zhang, Xue-jing; Yan, Ming^*

来源：Tetrahedron Letters, 2015, 56(2): 478-481.

DOI：10.1016/j.tetlet.2014.12.002

• Indole
• Intramolecular cyclization
• Amine
• Alkyne
• Free radical reaction

2-Aryl indoles could be prepared in excellent yields via the intramolecular cyclization of o-alkynyl N,N-dialkylanilines. The reaction is efficiently promoted by the catalytic amount of KOr-Bu in DMSO at room temperature. A reaction mechanism involving alpha-aminoalkyl radical intermediates is suggested.

• 出版日期2015-1-8
• 单位中山大学