Natural product syntheses via carbonylative cyclizations

作者：Ma, Kaiqing; Martin, Brandon S.; Yin, Xianglin; Dai, Mingji^*

来源：Natural Product Reports, 2019, 36(1): 174-219.

DOI：10.1039/c8np00033f

• ASYMMETRIC TOTAL-SYNTHESIS
• PAUSON-KHAND REACTION
• PALLADIUM-CATALYZED CARBONYLATION
• ENANTIOSELECTIVE TOTAL-SYNTHESIS
• CONCISE FORMAL SYNTHESIS
• C-H ACTIVATION
• RH(I)-CATALYZED (3+2)+1 CYCLOADDITION
• DIASTEREOSELECTIVE TOTAL-SYNTHESIS
• STEREOCONTROLLED TOTAL SYNTHESES
• STEREOSELECTIVE TOTAL SYNTHESES

In this review, we highlight recent examples of natural product total syntheses employing transition metal-mediated/catalyzed carbonylative cyclization strategies to build key ring systems. It mainly covers carbonylative cyclizations for the construction of O-heterocycles, N-heterocycles and carbocycles including cyclic ketones and phenols. The reaction types include carbonylation of epoxide to beta-lactones, carbonylative (macro)lactonization/lactamization, the Semmelhack reaction, tandem hydroformylation-cyclization, the Pauson-Khand reaction, carbonylative C-H activation cyclization, the Stille/Suzuki carbonylation, [n + m + 1] carbonylative cycloaddition, the Dotz annulation, and others.

• 出版日期2019-1-1
• 单位山西大学