A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitroglycerin as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis

作者：Tomoda Takeshi^*; Kato Hironari; Mizukawa Sho; Muro Shinichiro; Akimoto Yutaka; Uchida Daisuke; Matsumoto Kazuyuki; Yamamoto Naoki; Horiguchi Shigeru; Tsutsumi Koichiro; Okada Hiroyuki

来源：Acta Medica Okayama, 2016, 70(5): 405-408.

• post-ERCP pancreatitis
• NSAIDs
• nitroglycerin

Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography (ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitroglycerin might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitroglycerin for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitroglycerin can prevent PEP.

• 出版日期2016-10