The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

作者：Pereira Licia P; Kohler Cristiano A; de Sousa Rafael T; Solmi Marco; de Freitas Barbara P; Fornaro Michele; Machado Vieira Rodrigo; Miskowiak Kamilla W; Vieta Eduard; Veronese Nicola; Stubbs Brendon; Carvalho Andre F

来源：Neuroscience and Biobehavioral Reviews, 2017, 79: 87-109.

DOI：10.1016/j.neubiorev.2017.05.002

• Bipolar disorder
• Genetic polymorphisms
• Neuroimaging
• Magnetic resonance imaging
• Functional MRI
• Diffusion tensor imagingvoxel based morphometry

Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N= 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in> 2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

• 出版日期2017-8
• 单位NIH