Short-term increase of body weight triggers immunological variables in dogs

作者：Van de Velde H^*; Janssens G P J; Stuyven E; Cox E; Buyse J; Hesta M

来源：Veterinary Immunology and Immunopathology, 2012, 145(1-2): 431-437.

DOI：10.1016/j.vetimm.2011.12.021

• Weight gain
• Immunity
• Dog

Overweight in dogs is, as in other companion animals, a major risk factor for several metabolic disorders. However, it is not yet known whether immunity is challenged by increased body weight in dogs. The aim of this study was to investigate the effect of a short-term increase in body weight on immunological variables in adult healthy beagle dogs. Sixteen dogs, divided into a control group (CG) and weight gain group (WGG), were included. During a period of 13 weeks, the CG was fed at maintenance energy requirement (MER), whereas the WGG received a double amount of food. After 13 weeks, blood samples were taken for immunological and biochemical analyses. Weight gain and increased body condition score in the WGG were accompanied by a significant higher leptin concentration. Weight gain increased the number of lymphocytes and immunoglobulins A and M and was responsible for a higher proliferation of peripheral blood mononuclear cells (PBMC). Short-term increase of body weight thus seems to trigger immunological variables in dogs.

• 出版日期2012-1-15