A novel anthracene-based fluorescent colorimetric sensor for the simple naked-eye diagnosis of methylmalonic aciduria

作者：Miyaji Hidekazu^*; Fujimoto Junko; Mabuchi Riho; Okumura Moeno; Goto Shoichiro; Honda Youtaro

来源：Tetrahedron Letters, 2017, 58(37): 3623-3627.

DOI：10.1016/j.tetlet.2017.08.001

• Anthracene
• Amidopyridine
• Fluorescent colorimetric sensor
• Naked-eye diagnosis
• Methylmalonic aciduria

A novel molecular sensor using anthracene bearing two amidopyridines emits blue fluorescence in the presence of succinic acid and green fluorescence in the presence of malonic acid, and its fluorescence intensity increased upon binding. Using this molecular sensor, we succeeded in detecting the difference of one carbon atom between succinic acid and malonic acid with the naked-eye. Furthermore, when methylmalonic acid was dissolved in urine to provide a model system for methylmalonic aciduria, the fluorescence changed from blue to green, and methylmalonic acid was successfully detected with the naked-eye.

• 出版日期2017-9-13