delta-protocadherins: a gene family expressed differentially in the mouse brain

作者：Vanhalst K; Kools P; Staes K; van Roy F; Redies C^*

来源：Cellular and Molecular Life Sciences, 2005, 62(11): 1247-1259.

DOI：10.1007/s00018-005-5021-7

• cell adhesion
• cene structure
• alternative splicing
• protein phosphatase-1 alpha
• brain development
• expression pattern

Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta 1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta 2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta 1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1 alpha. Like most classic cadherins, each of three delta 1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta 1-protocadherins. Together, these results suggest that the members of the M-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.

• 出版日期2005-6