Deficient DNA repair in the human progeroid disorder, Werner syndrome

作者：Bohr VA^*

来源：Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2005, 577(1-2): 252-259.

DOI：10.1016/j.mrfmmm.2005.03.021

• Werner syndrome
• RecQ helicases
• DNA repair

The study of how DNA repair mechanisms change with aging is central to our understanding of the aging process. Here, I review the molecular functions of a key aging protein, Werner protein (WRN), which is deficient in the premature aging disorder, Werner syndrome (WS). This protein plays a significant role in DNA repair, particularly in base excision repair and in recombination. WRN may be a key regulatory factor in these processes and may also play a role in coordinating them. WRN belongs to the RecQ helicase family of proteins, often referred to as the guardians of the genome. These proteins appear to integrate with the more classic DNA repair pathways and proteins. Published by Elsevier B.V.

• 出版日期2005-9-4