A novel peptide interferes with Mycobacterium tuberculosis virulence and survival

作者:Samuchiwal Sachin Kumar; Tousif Sultan; Singh Dhiraj Kumar; Kumar Arun; Ghosh Anamika; Bhalla Kuhulika; Prakash Prem; Kumar Sushil; Trivedi Ashish Chandra; Bhattacharyya Maitree; Das Gobardhan; Ranganathan Anand*
来源:FEBS Open Bio, 2014, 4(1): 735-740.
DOI:10.1016/j.fob.2014.08.001

摘要

Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates. Here, we report that SL3, a novel 33-amino acid peptide, causes debilitating effects on mycobacterial morphology. Treatment with SL3 drastically inhibits the growth of Mycobacterium tuberculosis in vitro as well as in a pre-clinical mouse model for M.tb infection. Microarray analysis of SL3-expressing strain demonstrates wide-scale transcriptional disruption in M.tb. We therefore believe that SL3 and similar peptides may herald a new approach towards discovering new molecules for TB therapy.

  • 出版日期2014