Development of a cell permeable red-shifted CHEF-based chemosensor for Al3+ ion by controlling PET

作者：Mukherjee Manjira; Sen Buddhadeb; Pal Siddhartha; Maji Abhishek; Budhadev Darshita; Chattopadhyay Pabitra^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2016, 157: 11-16.

DOI：10.1016/j.saa.2015.11.032

• Chemosensor
• PET control
• CHEF
• Red shift
• Aluminium(III)

A structurally modified quinazoline derivative (L) acts as highly selective chemosensor for Al3+ ions in DMSO H2O (1:9, v/v) over the other competitive metal ions. L shows a red shifted fluorescence after the addition of Al3+ ions and later the further fluorescence enhancement is due to chelation enhanced fluorescence (CHEF) through inhibition of photoinduced electron transfer (PET). This probe (L) detects Al3+ ions as low as 9 nM in DMSO H2O (1:9, v/v) at biological pH. The non-cytotoxic probe (L) can efficiently detect the intercellular distribution of Al3+ ions in living cells under a fluorescence microscope to exhibit its sensible applications in the biological systems.

• 出版日期2016-3-15