A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians

作者：Oskina Natalia A^*; Boyarskikh Ulyana A; Lazarev Alexandr F; Petrova Valentina D; Ganov Dmitry I; Tonacheva Olga G; Lifshits Galina I; Filipenko Maxim L

来源：Urologic Oncology-Seminars and Original Investigations, 2014, 32(1): 37.e7-37.e12.

DOI：10.1016/j.urolonc.2013.02.017

• Prostate cancer
• Single nucleotide polymorphisms (SNPs)
• Russian
• Region of chromosome 8q24

Introduction: Multiple genetic studies have confirmed association of 8(124 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown.
Materials and methods: In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8(124 SN-Ps were genotyped by real-time polymerase chain reaction in histologically confirmed CaP "cases" (n = 392) and clinically evaluated "controls" (n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression: differences were considered statistically significant if P < 0.05.
Results: We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37 2.81], P < 0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P < 0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59-3.85], P < 0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73-1.11], P > 0.05.
Conclusion: Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population.

• 出版日期2014-1