Antibacterial, tyrosinase, and DNA photocleavage studies of some triazolylnucleosides

作者：Kumar Surender; Sukhvinder; Kumar Vinod; Gupta Girish Kumar; Beniwal Vikas; Abdmouleh Fatma; Ketata Emna; El Arbi Mehdi

来源：NUCLEOSIDES NUCLEOTIDES %26 NUCLEIC ACIDS, 2017, 36(8): 543-551.

DOI：10.1080/15257770.2017.1342830

• Antibacterial
• tyrosinase
• DNA photocleavage
• triazolylnucleosides

In order to explore the biological potential, some synthesized triazolylnucleosides were evaluated for their antibacterial, tyrosinase and DNA photocleavage activities. Triazolylnucleosides (5-12) were screened against Staphylococcus aureus (ATCC 6538), gram-positive and Escherichia coli (ATCC 10536), gram-negative bacterial strains. Among the series, compound 9 exhibited a significant level of antibacterial activity against both strains at higher concentration in reference to the standard drug, Levofloxacin. Tyrosinase activity and inhibition of these compounds were also studied, and it has been found that compounds 8 and 11 displayed more than 50% inhibitory activity. In addition, six compounds (7-12) were evaluated for their DNA photocleavage activity. The compounds 8 and 12 exhibited excellent DNA photocleavage activity at a concentration of 10 mu g and may be used as template for antitumor drugs in the future.

• 出版日期2017