科研之友
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摘要
Dear Editor, The close genetic and physiological similarity to humans make non-human primates (NHPs) excellent models for biomedical research [1].Genetically modified monkey models are invaluable for recapitulating human diseases.Reprogrammable nuclease CRISPR/Cas9 shows tremendous potentials for gene targeting in monkeys.The nuclease causes double-stranded breaks,which results in gene knockout when the breaks are repaired by non-homologous end-joining (NHEJ),or gene knockin when repaired by homology-directed repair (HDR) in the presence of exogenous templates [2].
