Non-interferometric photoacoustic remote sensing microscopy

作者：Hajireza Parsin^*; Shi Wei; Bell Kevan; Paproski Robert J; Zemp Roger J^*

来源：Light: Science and Applications , 2017, 6(6): e16278.

DOI：10.1038/lsa.2016.278

• all optical
• medical imaging
• optical resolution
• photoacoustic
• remote sensing

Elasto-optical refractive index modulation due to photoacoustic initial pressure transients produced significant reflection of a probe beam when the absorbing interface had an appreciable refractive index difference. This effect was harnessed in a new form of non-contact optical resolution photoacoustic microscopy called photoacoustic remote sensing microscopy. A non-interferometric system architecture with a low-coherence probe beam precludes detection of surface oscillations and other phase-modulation phenomenon. The probe beam was confocal with a scanned excitation beam to ensure detection of initial pressure-induced intensity reflections at the subsurface origin where pressures are largest. Phantom studies confirmed signal dependence on optical absorption, index contrast and excitation fluence. In vivo imaging of superficial microvasculature and melanoma tumors was demonstrated with similar to 2.7 +/- 0.5 mu m lateral resolution.

• 出版日期2017-6-2