Detection of Xenotropic Murine Leukemia Virus-Related Virus in Prostate Biopsy Samples

作者：Baig Faraz Ahmed^*; Mirza Talat; Khanani Rafiq; Khan Saeed

来源：Journal of the College of Physicians and Surgeons Pakistan, 2014, 24(9): 636-639.

• Xenotropic murine leukemia virus related virus (XMRV)
• Pakistan
• Prostate cancer
• Gleason score

Objective: To determine the association of Xenotropic murine leukemia virus related virus (XMRV) infection with prostate cancer and compare it with benign prostate hyperplasia.
Study Design: Case control study.
Place and Duration of Study: Department of Histopathology and Molecular Pathology, Dow University of Health Sciences, Karachi, from January 2009 to December 2012.
Methodology: XMRV was screened in 50 prostate cancer and 50 benign prostatic hyperplasia biopsies using conventional end-point PCR. Other studied variables were family history of prostate cancer, patients age and Gleason score.
Results: XMRV was detected in 4 (8%) of the 50 prostate cancer biopsy specimens compared to none in biopsies with benign prostatic hyperplasia. However, there was no significant statistical association of XMRV infection with the other variables.
Conclusion: A low frequency of XMRV infection was found in this case-control study. Men, who harbor XMRV infection, may be at increased risk of prostate cancer but this needs to be investigated further at a larger scale.

• 出版日期2014-9