Discovery of prostate specific antigen pattern to predict castration resistant prostate cancer of androgen deprivation therapy

作者：Kim Yejin; Park Yong Hyun; Lee Ji Youl; Choi In Young; Yu Hwanjo^*

来源：BMC Medical Informatics and Decision Making, 2016, 16(S1): 63.

DOI：10.1186/s12911-016-0297-0

• Prostate specific antigen
• Longitudinal biomarker
• Frequent sequential pattern mining
• Prediction

Background: Prostate specific antigen (PSA) is an important biomarker to monitor the response to the treatment, but has not been fully utilized as a whole sequence. We used a longitudinal biomarker PSA to discover a new prognostic pattern that predicts castration-resistant prostate cancer (CRPC) after androgen deprivation therapy.
Methods: We transformed the longitudinal PSA into a discrete sequence, used frequent sequential pattern mining to find candidate patterns from the sequences, and selected the most predictive and informative pattern among the candidates.
Results: Patients were less likely to be CRPC if, after PSA values reach nadir, the PSA decreases more than 0.048 ng/ml during a month, and the decrease occurs again. This pattern significantly increased the accuracy of predicting CRPC by supplementing information provided by existing PSA patterns such as pretreatment PSA.
Conclusions: This result can help clinicians to stratify men by the risk of CRPC and to determine the patient that needs intensive follow-up.

• 出版日期2016-7-18