Amine-functionalized mesoporous silica KIT 6 as a controlled release drug delivery carrier

作者：Ayad Mohamad M^*; Salahuddin Nehal A; Abu El Nasr Ahmed; Torad Nagy L

来源：Microporous and Mesoporous Materials, 2016, 229: 166-177.

DOI：10.1016/j.micromeso.2016.04.029

• Mesoporous silica KIT-6
• Sol-gel method
• Drug delivery
• Quartz crystal microbalance (QCM)

Mesoporous silica KIT-6, has been prepared through the sol-gel method followed by a chemical modification using 3-aminopropyl triethoxysilane (APTS) to obtain KIT-6-NH2 as a drug delivery carrier. The mesostructure properties was fully characterized by transmission electron microscope (TEM), N-2 sorption isotherm, Fourier transform infrared (FT-IR), low-angel X-ray diffraction (XRD) and small-angel x-ray scattering (SAXS). Loading of ketoprofen (KP) and 5-flurouracil (5-FU) drugs as models into KIT-6 and KIT-6-NH2 was studied using quartz crystal microbalance (QCM) and UV visible spectroscopy. The loading uptake and release behaviors of KP and 5-FU were highly dependent on the textural properties of KIT-6 and KIT-6-NH2. The release of drugs was carefully studied in simulated gastric fluid (pH 2) and in simulated intestinal fluid (pH 7.4). First order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas release kinetic models were applied to the experimental data and the release was found to obey a first-order rate kinetic.

• 出版日期2016-7-15