科研之友
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摘要
Phosphoric acid derivatives operate as effective catalysts for the synthesis of glycines in high yield through multicomponent coupling reactions of nitrodiazoesters, anilines, and indoles. This interesting process requires double polarity reversal, or umpolung, of the ester functionality: two nucleophiles undergo addition to the carbon alpha to an ester. Modest control over the absolute stereochemistry of the glycine products is attainable under the influence of chiral BINOL-based phosphoric-acid-derived catalysis.
- 出版日期2014-4
